Lack of association between HLA DQB1 alleles with HPV infection and histology findings in cervical cancer in Australian women

S. Chen; S. N. Tabrizi; H. O'Sullivan; C. K. Fairley; M. A. Quinn; S. M. Garland

doi:10.1046/j.1525-1438.1999.99030.x

Lack of association between HLA DQB1 alleles with HPV infection and histology findings in cervical cancer in Australian women

Int J Gynecol Cancer. 1999 May;9(3):220-224. doi: 10.1046/j.1525-1438.1999.99030.x.

Authors

S. Chen¹, S. N. Tabrizi, H. O'Sullivan, C. K. Fairley, M. A. Quinn, S. M. Garland

Affiliation

¹ Department of Microbiology & Infectious Disease, The Royal Women's Hospital, Carlton Victoria, Australia; Department of Oncology, The Royal Women's Hospital, Carlton Victoria, Australia; Department of Epidemiology and Preventive Medicine, Monash University, Alfred Hospital, Prahran, Victoria, Australia.

PMID: 11240770
DOI: 10.1046/j.1525-1438.1999.99030.x

Abstract

The association of human leukocyte antigen (HLA) types with cervical cancer and human papillomavirus (HPV) infection is controversial. In this study we examined 186 Australian women who had biopsy-confirmed cervical cancer and detected HLA DQB1 alleles and HPV DNA, using the polymerase chain reaction (PCR) amplification and sequence specific oligonucleotides probe (SSOP) hybridization methods. We analyzed the frequencies of 11 DQB1 alleles according to HPV DNA status (HPV positivity and HPV genotyping) and histology (tumor type, staging, grades, lymphocyte infiltration and nodal status). No significant differences among these 11 HLA DQB1 alleles were found with respect to HPV status and histology.