The process of epileptogenesis: a pathophysiological approach

Curr Opin Neurol. 2001 Apr;14(2):187-92. doi: 10.1097/00019052-200104000-00009.

Abstract

Several recent advances have contributed to our understanding of the processes associated with mesial temporal lobe epilepsy in humans and in experimental animal models. Common pathological features between the human condition and the animal models may indicate a fundamental involvement of the given pathology in the process of epileptogenesis.

Publication types

  • Review

MeSH terms

  • Animals
  • Disease Models, Animal
  • Epilepsy, Temporal Lobe / etiology*
  • Epilepsy, Temporal Lobe / pathology
  • Epilepsy, Temporal Lobe / physiopathology*
  • Glutamic Acid / metabolism
  • Hippocampus / metabolism
  • Hippocampus / pathology*
  • Hippocampus / physiopathology*
  • Humans
  • Interneurons / metabolism
  • Interneurons / pathology
  • Mossy Fibers, Hippocampal / metabolism
  • Mossy Fibers, Hippocampal / pathology
  • Neural Inhibition / physiology
  • Neuronal Plasticity / physiology
  • gamma-Aminobutyric Acid / metabolism

Substances

  • Glutamic Acid
  • gamma-Aminobutyric Acid