Abstract
A beta-turn overlay hypothesis has been used to transform the core scaffold of a selective non-peptide bradykinin B2 receptor antagonist into ligands specifically recognized by the CCK2 or NK1 receptors.
MeSH terms
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Animals
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Brain Chemistry
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Drug Design
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Enzyme Inhibitors / chemistry
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In Vitro Techniques
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Ligands
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Models, Molecular
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Molecular Structure
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Nitro Compounds / chemical synthesis
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Nitro Compounds / chemistry*
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Nitro Compounds / metabolism*
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Peptides / chemistry*
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Protein Conformation
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Radioligand Assay
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Receptors, Cholecystokinin / chemistry
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Receptors, Cholecystokinin / metabolism*
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Receptors, Neurokinin-1 / chemistry
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Receptors, Neurokinin-1 / metabolism*
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Semicarbazides / chemistry*
Substances
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Enzyme Inhibitors
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Ligands
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Nitro Compounds
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Peptides
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Receptors, Cholecystokinin
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Receptors, Neurokinin-1
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Semicarbazides
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thiosemicarbazide