Cytokines: IL-21 joins the gamma(c)-dependent network?

Curr Biol. 2001 Mar 6;11(5):R175-7. doi: 10.1016/s0960-9822(01)00087-2.

Abstract

The discovery of the cytokine IL-21 adds another member to the ever-growing list of small secreted molecules that have potent effects on lymphoid cells. Initial characterization of the IL-21 receptor complex suggests that IL-21 may belong to the cytokine family whose receptors share the common gamma chain, gamma(c).

MeSH terms

  • Animals
  • CD4-Positive T-Lymphocytes / immunology
  • CD4-Positive T-Lymphocytes / metabolism
  • CD4-Positive T-Lymphocytes / physiology
  • CD8-Positive T-Lymphocytes / immunology
  • CD8-Positive T-Lymphocytes / metabolism
  • CD8-Positive T-Lymphocytes / physiology
  • Cytotoxicity, Immunologic / immunology
  • DNA-Binding Proteins / metabolism
  • Humans
  • Interleukin-21 Receptor alpha Subunit
  • Interleukins / classification
  • Interleukins / genetics
  • Interleukins / immunology*
  • Interleukins / metabolism
  • Janus Kinase 1
  • Killer Cells, Natural / immunology*
  • Killer Cells, Natural / metabolism
  • Killer Cells, Natural / physiology
  • Milk Proteins*
  • Protein-Tyrosine Kinases / metabolism
  • Receptors, Interleukin / classification
  • Receptors, Interleukin / genetics
  • Receptors, Interleukin / immunology*
  • Receptors, Interleukin / metabolism
  • Receptors, Interleukin-21
  • STAT5 Transcription Factor
  • Signal Transduction / immunology*
  • Trans-Activators / metabolism

Substances

  • DNA-Binding Proteins
  • IL21R protein, human
  • Interleukin-21 Receptor alpha Subunit
  • Interleukins
  • Milk Proteins
  • Receptors, Interleukin
  • Receptors, Interleukin-21
  • STAT5 Transcription Factor
  • Trans-Activators
  • Protein-Tyrosine Kinases
  • JAK1 protein, human
  • Janus Kinase 1
  • interleukin-21