Aim: To observe the effects of four drugs, ligustrazine (Lig), tanshinone II A (Tan), ubiquinone (Ubi) and idebenone (Ide), on learning and memory of mouse.
Methods: Mouse water maze was used to evaluate nootropic effect.
Results: In comparison with the defective model (only scopolamine 3 mg.kg-1, Tan 20 mg.kg-1, ig) shortened the escape latency dramatically from (36 +/- 19) s to (11 +/- 5) s (P < 0.01) and reduced errors from 7 +/- 5 to 1.5 +/- 1.3 (P < 0.05). Ubi 20 mg.kg-1 ig decreased the escape latency from (37 +/- 18) s to (17 +/- 12) s and errors from 8 +/- 5 to 2.1 +/- 2.7 (P < 0.01). Ide 120 mg.kg-1 (ig) reduced the errors from 8 +/- 6 to 3.4 +/- 2.9 (P < 0.05), but had no remarkable effect on the escape latency. Lig did not exhibit marked effect on the deficit.
Conclusion: Tan, Ubi, and Ide improved scopolamine-caused spatial performance defects in mouse.