Systemic lupus erythematosus in a 1-year-old child

Am J Dis Child. 1975 Jan;129(1):123-5. doi: 10.1001/archpedi.1975.02120380093022.

Abstract

An 11-month-old girl had systemic lupus erythematosus with a widespread skin rash. She manifested five of the criteria necessary for the diagnosis: oral ulcerations, alopecia, positive lupus erythematosus preparations, convulsions, and thrombocytopenia with leukopenia. Direct immunofluorescence showed deposits of IgG and C3 at the dermoepidermal junction of both abnormal and clinically uninvolved skin, and in subepithelial deposits along the glomerular basement membrane.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Age Factors
  • Alopecia / etiology
  • Complement C3 / analysis
  • Female
  • Humans
  • Immunoglobulin G / analysis
  • Infant
  • Leukopenia / etiology
  • Lupus Erythematosus, Systemic* / diagnosis
  • Lupus Erythematosus, Systemic* / drug therapy
  • Lupus Erythematosus, Systemic* / immunology
  • Microscopy, Fluorescence
  • Oral Manifestations
  • Penicillins / adverse effects
  • Penicillins / therapeutic use
  • Seizures / etiology
  • Skin / immunology
  • Sulfisoxazole / adverse effects
  • Sulfisoxazole / therapeutic use
  • Thrombocytopenia / etiology
  • Ulcer / etiology

Substances

  • Complement C3
  • Immunoglobulin G
  • Penicillins
  • Sulfisoxazole