Abstract
Solid tumors require neovascularization for growth and metastasis. Angiogenesis depends on the local balance between various molecules that induce and inhibit neovascularization. Thrombospondin-1 (TSP-1) is thought to be an antiangiogenic factor. In this study, we examined the correlation between expression of TSP-1 and tumor vascularity, and determined its prognostic significance in colon cancer. Microvessel density, determined by immunostaining for factor VIII-related antigen, was significantly higher in tumors that were TSP-1-negative. TSP-1 expression was inversely correlated with prognosis. Patients with TSP-1-negative tumors had a significantly worse prognosis than did those with TSP-1-positive tumors. Frequency of hepatic recurrence was significantly higher in patients with tumors that were TSP-1-negative. In conclusion, TSP-1 is an important negative-regulator of tumor angiogenesis, and TSP-1 may be useful for predicting recurrence in patients with colon cancer.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenocarcinoma / blood supply*
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Adenocarcinoma / metabolism
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Adenocarcinoma / pathology
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Adult
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Aged
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Colonic Neoplasms / blood supply*
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Colonic Neoplasms / metabolism
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Colonic Neoplasms / pathology
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Disease-Free Survival
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Endothelial Growth Factors
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Endothelium, Vascular / metabolism
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Endothelium, Vascular / pathology
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Factor VIII / metabolism
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Female
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Humans
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Immunoenzyme Techniques
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Liver Neoplasms / secondary*
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Lymph Nodes / metabolism
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Lymph Nodes / pathology
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Lymphatic Metastasis
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Lymphokines
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Male
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Middle Aged
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Neoplasm Invasiveness
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Neoplasm Recurrence, Local
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Neovascularization, Pathologic / metabolism*
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Neovascularization, Pathologic / pathology
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Peritoneal Neoplasms / secondary*
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Prognosis
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Thrombospondin 1 / metabolism*
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Vascular Endothelial Growth Factor A
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Vascular Endothelial Growth Factors
Substances
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Endothelial Growth Factors
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Lymphokines
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Thrombospondin 1
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Vascular Endothelial Growth Factor A
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Vascular Endothelial Growth Factors
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Factor VIII