Abstract
There is widespread agreement that mitochondria have a function in apoptosis, but the mechanisms behind their involvement remain controversial. Here we suggest that opening of a multiprotein complex called the mitochondrial permeability transition pore complex is sufficient (and, usually, necessary) for triggering apoptosis.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Apoptosis / physiology*
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Intracellular Membranes / physiology
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Mitochondria / physiology*
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Mitochondrial ADP, ATP Translocases / pharmacology
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Models, Biological
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Permeability
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Porins / physiology
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Proto-Oncogene Proteins / physiology
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Proto-Oncogene Proteins c-bcl-2 / physiology
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Voltage-Dependent Anion Channels
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bcl-2-Associated X Protein
Substances
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Porins
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Proto-Oncogene Proteins
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Proto-Oncogene Proteins c-bcl-2
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Voltage-Dependent Anion Channels
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bcl-2-Associated X Protein
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Mitochondrial ADP, ATP Translocases