A pharmacokinetic model for factor VIII dosing during active haemorrhage in patients with haemophilia A

A M Ho; P Dion; M K Karmakar; G Cheng; J L Derrick; D C Chung; B A Tay

doi:10.1046/j.1365-2044.2001.02058-3.x

A pharmacokinetic model for factor VIII dosing during active haemorrhage in patients with haemophilia A

Anaesthesia. 2001 Aug;56(8):785-90. doi: 10.1046/j.1365-2044.2001.02058-3.x.

Authors

A M Ho¹, P Dion, M K Karmakar, G Cheng, J L Derrick, D C Chung, B A Tay

Affiliation

¹ Department of Anaesthesia and Intensive Care, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China hoamh@cuhk.edu.hk.

PMID: 11493246
DOI: 10.1046/j.1365-2044.2001.02058-3.x

Abstract

A theoretical one-compartment pharmacokinetic model is described, the aim of which is to guide factor VIII replacement therapy in patients with haemophilia A suffering from significant and ongoing haemorrhage. Based on our calculations, plasma factor VIII concentrations can decrease at a rapid rate even with non-severe blood loss.

MeSH terms

Factor VIII / pharmacokinetics*
Factor VIII / therapeutic use
Hemophilia A / complications*
Hemophilia A / drug therapy
Hemophilia A / metabolism
Hemorrhage / drug therapy*
Hemorrhage / metabolism
Humans
Models, Biological*

Substances

Factor VIII