Abstract
The mechanism for the formation of active oxygen species and their reactions with antioxidants is described. The importance of the free radical chain oxidation and the singlet oxygen-dependent oxidation is suggested by a decrease in skin levels of alpha-tocopherol, ubiquinol-10, and ascorbic acid with a concomitant formation of lipid hydroperoxides during UV irradiation of murine skin, and the formation of squalene hydroperoxides in human skin upon UV exposure, respectively.
MeSH terms
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Animals
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Antioxidants / metabolism*
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Ascorbic Acid / metabolism
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Cholesterol Esters / metabolism
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Free Radicals
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Phosphatidylcholines / metabolism
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Rats
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Reactive Oxygen Species / metabolism*
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Skin / metabolism
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Skin / radiation effects*
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Skin Aging / physiology*
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Skin Aging / radiation effects*
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Ubiquinone / analogs & derivatives*
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Ubiquinone / metabolism
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Ultraviolet Rays*
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Vitamin E / metabolism
Substances
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Antioxidants
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Cholesterol Esters
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Free Radicals
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Phosphatidylcholines
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Reactive Oxygen Species
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phosphatidylcholine hydroperoxide
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Ubiquinone
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Vitamin E
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cholesteryl ester hydroperoxide
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ubiquinol-10
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Ascorbic Acid