Abstract
The NPS-1 and TLE-1 beta-lactamase genes were cloned and sequenced. NPS-1 differed from LCR-1 beta-lactamase in 8 of 260 amino acids. TLE-1 differed from TEM-1 by a single Asp(115)-->Gly substitution and has been renamed TEM-90.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Amino Acid Sequence
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Bacterial Proteins*
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Cloning, Molecular
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Escherichia coli / enzymology*
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Escherichia coli / genetics
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Humans
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Molecular Sequence Data
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Pseudomonas aeruginosa / enzymology*
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Pseudomonas aeruginosa / genetics
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Sequence Homology, Amino Acid
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beta-Lactamases / chemistry
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beta-Lactamases / genetics*
Substances
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Bacterial Proteins
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NPS-1 beta-lactamase
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TLE-1 beta-lactamase
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beta-lactamase LCR-1, Bacteria
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beta-Lactamases