Survival following Burkholderia cepacia sepsis in a patient with cystic fibrosis treated with corticosteroids

Pediatr Pulmonol. 2001 Oct;32(4):338-40. doi: 10.1002/ppul.1127.

Abstract

We describe an 11-year-old girl with cystic fibrosis (CF) who presented with respiratory failure and Burkholderia cepacia bacteremia (cepacia syndrome). She survived her illness after aggressive treatment with parenteral antibiotics and corticosteroids. We speculate that treatment with corticosteroids may decrease the influx of proinflammatory cytokines and neutrophil-induced inflammation, with resulting improvement in the outcome of cepacia syndrome in CF patients.

Publication types

  • Case Reports

MeSH terms

  • Anti-Bacterial Agents / administration & dosage
  • Anti-Inflammatory Agents / administration & dosage
  • Bacteremia / complications
  • Bacteremia / diagnosis
  • Bacteremia / drug therapy*
  • Burkholderia Infections / complications
  • Burkholderia Infections / diagnosis
  • Burkholderia Infections / drug therapy*
  • Burkholderia cepacia / isolation & purification*
  • Child
  • Combined Modality Therapy
  • Cystic Fibrosis / complications
  • Cystic Fibrosis / drug therapy*
  • Female
  • Follow-Up Studies
  • Humans
  • Methylprednisolone / administration & dosage*
  • Opportunistic Infections / complications
  • Opportunistic Infections / diagnosis
  • Opportunistic Infections / drug therapy*
  • Severity of Illness Index
  • Treatment Outcome

Substances

  • Anti-Bacterial Agents
  • Anti-Inflammatory Agents
  • Methylprednisolone