Abstract
Immunity to mycobacterial antigens may contribute to the maintenance of self-tolerance. Exposure of the immune system to mycobacterial antigen might well stimulate the immune system to exert control over unwanted self-reactive clones. We demonstrated that in vivo administration of Mycobacterium tuberculosis, PPD, and PPD peptide (180-196) prior to immunization with Myelin Basic Protein (MBP) led to a moderate increase of gammadelta T cells, suppression of the immune response, and reduction in the severity of Experimental Autoimmune Encephalomyelitis. The immunosuppression observed is due, at least in part, to the production of Transforming growth factor-beta (TGFbeta) by the gammadelta T lymphocytes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adoptive Transfer
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Animals
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Antigenic Modulation
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Antigens, Bacterial / immunology*
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Antigens, Bacterial / pharmacology
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Cell Division / immunology
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Cells, Cultured
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Encephalomyelitis, Autoimmune, Experimental / immunology*
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Female
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Lymphocyte Activation / immunology
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Mycobacterium / immunology*
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Myelin Basic Protein / immunology
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Myelin Basic Protein / pharmacology
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Rats
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Rats, Inbred Lew
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Receptors, Antigen, T-Cell, gamma-delta / drug effects
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Receptors, Antigen, T-Cell, gamma-delta / immunology*
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T-Lymphocytes / cytology
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T-Lymphocytes / immunology*
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Transforming Growth Factor beta / biosynthesis
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Tuberculin / pharmacology
Substances
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Antigens, Bacterial
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Myelin Basic Protein
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Receptors, Antigen, T-Cell, gamma-delta
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Transforming Growth Factor beta
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Tuberculin