Studies on the hypoglycaemic activity of Punica granatum seed in streptozotocin induced diabetic rats

Phytother Res. 2001 Nov;15(7):628-9. doi: 10.1002/ptr.740.

Abstract

The hypoglycaemic activity of Punica granatum Linn. (Family Punicaceae) seed extract on rats made diabetic by streptozotocin (STZ) was investigated. The methanol extract of the seed at doses of 300 and 600 mg/kg, and chlorpropamide 200 mg/kg was administered to STZ diabetic rats. The seed extract (150, 300 and 600 mg/kg, orally) caused a significant reduction of blood glucose levels in STZ induced diabetic rats by 47% and 52%, respectively, at the end of 12 h.

MeSH terms

  • Administration, Oral
  • Animals
  • Blood Glucose / metabolism
  • Diabetes Mellitus / chemically induced
  • Diabetes Mellitus / drug therapy*
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Female
  • Hypoglycemic Agents / administration & dosage
  • Hypoglycemic Agents / therapeutic use*
  • Magnoliopsida*
  • Male
  • Phytotherapy*
  • Plant Extracts / administration & dosage
  • Plant Extracts / therapeutic use*
  • Rats
  • Rats, Wistar
  • Seeds
  • Streptozocin

Substances

  • Blood Glucose
  • Hypoglycemic Agents
  • Plant Extracts
  • Streptozocin