Abstract
In the late 1980s, we have shown that the E1A gene can downregulate HER-2/neu overexpression, thus reversing the tumorigenic and metastatic phenotype. Further, E1A can function as a tumor suppressor gene by inducing apoptosis and inhibiting metastasis. At The University of Texas M. D. Anderson Cancer Center, we have been investigating the adenovirus type 5 E1A gene as a potential therapeutic gene in breast and ovarian cancer since 1995 by using cationic liposome as gene delivery system. In this chapter, we recount our development of E1A as a therapeutic gene.
Publication types
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Comparative Study
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Lecture
MeSH terms
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Adenovirus E1A Proteins / administration & dosage*
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Adenovirus E1A Proteins / genetics*
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Animals
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Breast Neoplasms / genetics
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Breast Neoplasms / therapy*
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Clinical Trials, Phase I as Topic
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Disease Models, Animal
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Female
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Follow-Up Studies
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Genes, Tumor Suppressor / physiology*
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Genetic Therapy / methods*
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Humans
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Mice
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Oncogene Proteins, Viral / administration & dosage*
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Ovarian Neoplasms / genetics
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Ovarian Neoplasms / therapy*
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Sensitivity and Specificity
Substances
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Adenovirus E1A Proteins
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Oncogene Proteins, Viral