Prostacyclin analogs as the brakes for pulmonary artery smooth muscle cell proliferation: is it sufficient to treat severe pulmonary hypertension?

Am J Respir Cell Mol Biol. 2002 Feb;26(2):171-4. doi: 10.1165/ajrcmb.26.2.f230.

Authors

Rubin M Tuder¹, Ari L Zaiman

Affiliation

¹ Division of Cardiopulmonary Pathology, Department of Pathology, The Johns Hopkins University School of Medicine, 720 Rutland Ave., Baltimore, MD 21205, USA. Rtuder@JHMI.EDU

PMID: 11804866
DOI: 10.1165/ajrcmb.26.2.f230

No abstract available

Publication types

Comment

MeSH terms

Animals
Antihypertensive Agents / chemistry
Antihypertensive Agents / pharmacology
Antihypertensive Agents / therapeutic use
Cell Division / drug effects
Epoprostenol / analogs & derivatives*
Epoprostenol / chemistry
Epoprostenol / pharmacology
Epoprostenol / physiology*
Humans
Hypertension, Pulmonary / drug therapy
Hypertension, Pulmonary / etiology
Hypertension, Pulmonary / pathology
Hypertension, Pulmonary / physiopathology*
Lung / metabolism
Lung / pathology
Models, Biological
Muscle, Smooth, Vascular / cytology
Muscle, Smooth, Vascular / drug effects*
Muscle, Smooth, Vascular / metabolism
Pulmonary Artery / cytology
Pulmonary Artery / drug effects*
Pulmonary Artery / metabolism
Receptors, Epoprostenol
Receptors, Prostaglandin / metabolism
Signal Transduction / physiology

Substances

Antihypertensive Agents
Receptors, Epoprostenol
Receptors, Prostaglandin
Epoprostenol