The regulation and function of the Id proteins in lymphocyte development

Oncogene. 2001 Dec 20;20(58):8308-16. doi: 10.1038/sj.onc.1205091.

Abstract

Helix-loop-helix (HLH) proteins are essential factors for lymphocyte development and function. One class of HLH proteins, the E-proteins, regulate many aspects of lymphocyte maturation, survival, proliferation, and differentiation. E-proteins are negatively regulated by another class of HLH proteins known as the Id proteins. The Id proteins function as dominant negative inhibitors of E-proteins by inhibiting their ability to bind DNA. Here we discuss the function and regulation of the Id proteins in lymphocyte development.

MeSH terms

  • Animals
  • Cell Differentiation
  • Cell Division
  • Cell Lineage
  • Cell Transformation, Neoplastic / genetics
  • Clonal Deletion
  • DNA / metabolism
  • DNA-Binding Proteins / deficiency
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / physiology*
  • Female
  • Gene Expression Regulation, Developmental
  • H-Y Antigen / physiology
  • Helix-Loop-Helix Motifs
  • Hematopoiesis / genetics
  • Hematopoiesis / physiology*
  • Humans
  • Inhibitor of Differentiation Protein 1
  • Inhibitor of Differentiation Protein 2
  • Inhibitor of Differentiation Proteins
  • Lymphocyte Activation
  • Lymphocyte Subsets / cytology*
  • Lymphoma / genetics
  • MAP Kinase Signaling System
  • Male
  • Mice
  • Mice, Knockout
  • Mice, Transgenic
  • Models, Biological
  • Multigene Family*
  • Neoplasm Proteins*
  • Protein Kinases / physiology
  • Repressor Proteins*
  • TCF Transcription Factors
  • Transcription Factor 7-Like 1 Protein
  • Transcription Factors / deficiency
  • Transcription Factors / genetics
  • Transcription Factors / physiology*
  • Transcription, Genetic
  • Transforming Growth Factor beta / physiology

Substances

  • DNA-Binding Proteins
  • H-Y Antigen
  • ID1 protein, human
  • ID2 protein, human
  • ID4 protein, human
  • Idb1 protein, mouse
  • Idb2 protein, mouse
  • Idb4 protein, mouse
  • Inhibitor of Differentiation Protein 1
  • Inhibitor of Differentiation Protein 2
  • Inhibitor of Differentiation Proteins
  • Neoplasm Proteins
  • Repressor Proteins
  • TCF Transcription Factors
  • TCF7L1 protein, human
  • Tcf7l1 protein, mouse
  • Transcription Factor 7-Like 1 Protein
  • Transcription Factors
  • Transforming Growth Factor beta
  • ID3 protein, human
  • DNA
  • Protein Kinases