Molecular characterization and chromosome assignment of the porcine gene COX7A1 coding for the muscle specific cytochrome c oxidase subunit VIIa-M

Cytogenet Cell Genet. 2001;94(3-4):190-3. doi: 10.1159/000048814.

Abstract

The COX7A1 gene encodes a heart- and muscle-specific isoform of the subunit VIIA of cytochrome c oxidase, which is the last component of the mitochondrial electron transfer chain. Cloning and characterization of the porcine COX7A1 gene revealed a highly conserved organization with respect to other mammalian COX7A1 orthologs. The porcine gene consists of four exons spanning approximately 1.5 kb and codes for a peptide of 80 amino acids. The COX7A1 gene showed no variation between pigs from different breeds. The gene was assigned by FISH and RH-mapping to SSC 6q1.1-->q1.2 which is in agreement with previously established comparative maps.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chromosomes / genetics*
  • Electron Transport Complex IV / chemistry*
  • Electron Transport Complex IV / genetics*
  • Exons / genetics
  • In Situ Hybridization, Fluorescence
  • Isoenzymes / chemistry
  • Isoenzymes / genetics
  • Muscles / enzymology*
  • Mutation / genetics
  • Physical Chromosome Mapping*
  • Protein Subunits
  • Radiation Hybrid Mapping
  • Swine / genetics*

Substances

  • Isoenzymes
  • Protein Subunits
  • Electron Transport Complex IV