Benzamide-based thiolcarbamates: a new class of HIV-1 NCp7 inhibitors

Bioorg Med Chem Lett. 2002 Mar 11;12(5):767-70. doi: 10.1016/s0960-894x(02)00007-0.

Abstract

The HIV-1 nucleocapsid protein NCp7, which contains two highly conserved zinc fingers, is being used as a novel target for AIDS therapy due to its pivotal role in viral replication and its mutationally intolerant nature. Herein we report a new class of NCp7 inhibitors that possess good antiviral activity with low cellular toxicity.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Anti-HIV Agents / chemical synthesis*
  • Anti-HIV Agents / pharmacology
  • Benzamides / chemistry*
  • Capsid / antagonists & inhibitors*
  • Capsid Proteins*
  • Cell Survival / drug effects
  • Cells, Cultured
  • Gene Products, gag / antagonists & inhibitors*
  • HIV Infections / drug therapy
  • HIV-1 / drug effects*
  • HIV-1 / physiology
  • Humans
  • Monocytes / drug effects
  • Structure-Activity Relationship
  • Thiocarbamates / chemical synthesis*
  • Thiocarbamates / pharmacology
  • Tumor Necrosis Factor-alpha / pharmacology
  • Viral Proteins*
  • Zinc Fingers
  • gag Gene Products, Human Immunodeficiency Virus

Substances

  • Anti-HIV Agents
  • Benzamides
  • Capsid Proteins
  • Gene Products, gag
  • NCP7 protein, Human immunodeficiency virus 1
  • Thiocarbamates
  • Tumor Necrosis Factor-alpha
  • Viral Proteins
  • gag Gene Products, Human Immunodeficiency Virus