Objective: To provide information on the effects of the offspring of rats exposed to fluoride-arsenic.
Methods: The levels of lipid peroxidation and the abilities of antioxidation were determined in the blood of the rats and their offsprings under two generations-one nest reproductive test.
Results: The activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in the blood decreased with the increase of exposure dose. For example, the activity of SOD, was 14.56, 13.74, 11.89 and 11.21 micromol x min(-1) x mg Hb(-1) in different dose groups of F(2), respectively. In contrast, the concentration of lipid peroxides (LPO) increased. Eight weeks after exposure, the activities of SOD and GSH-Px increased, the activity of SOD was 13.97, 13.55, 13.47 and 12.76 micromol x min(-1) x mg Hb(-1), respectively, and the concentration of LPO returned to normal level.
Conclusion: Fluoride-arsenic exposure can cause oxidative damage of the rat's offspring.