Multivalent cyclooligosaccharides: versatile carbohydrate clusters with dual role as molecular receptors and lectin ligands

Carmen Ortiz Mellet; Jacques Defaye; José M García Fernández

doi:10.1002/1521-3765(20020503)8:9<1982::AID-CHEM1982>3.0.CO;2-5

Multivalent cyclooligosaccharides: versatile carbohydrate clusters with dual role as molecular receptors and lectin ligands

Chemistry. 2002 May 3;8(9):1982-90. doi: 10.1002/1521-3765(20020503)8:9<1982::AID-CHEM1982>3.0.CO;2-5.

Authors

Carmen Ortiz Mellet¹, Jacques Defaye, José M García Fernández

Affiliation

¹ Departamento de Química Orgánica Facultad de Química Universidad de Sevilla, Aptdo. 553, 41071 Sevilla, Spain.

PMID: 11981882
DOI: 10.1002/1521-3765(20020503)8:9<1982::AID-CHEM1982>3.0.CO;2-5

Abstract

Results obtained over the past decade towards the preparation of multitopic carbohydrate architectures combining the molecular inclusion capabilities of cyclomaltooligosaccharide receptors (cyclodextrins, CDs) and the recognition properties of saccharide ligands towards biological receptors are discussed. The potential of these new sugar-based "intelligent" transporters for site specific delivery of therapeutics is outlined.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Carbohydrate Conformation
Carbohydrate Sequence
Cyclodextrins / chemistry
Glycoconjugates / chemical synthesis
Glycoconjugates / chemistry*
Lectins / chemistry
Lectins / metabolism*
Ligands
Molecular Sequence Data
Molecular Structure
Oligosaccharides / chemical synthesis
Oligosaccharides / chemistry*
Receptors, Cell Surface / chemistry
Receptors, Cell Surface / metabolism*

Substances

Cyclodextrins
Glycoconjugates
Lectins
Ligands
Oligosaccharides
Receptors, Cell Surface