Abstract
1. Protease-activated receptor 2 (PAR2), present in capsaicin-sensitive sensory neurons, induces gastric mucus secretion and mucosal cytoprotection. 2. We studied the possible cross-talk between PAR2 and vanilloid receptor 1 (VR1). The VR1 antagonist capsazepine partially inhibited the PAR2-mediated increase in gastric mucus secretion. 3. Thus, activation of VR1 is responsible, at least in part, for the neurally mediated mucosal cytoprotection following activation of PAR2.
MeSH terms
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Animals
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Capsaicin / analogs & derivatives*
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Capsaicin / pharmacology*
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Gastric Mucosa / drug effects*
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Gastric Mucosa / innervation
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Gastric Mucosa / metabolism*
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Male
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Neural Inhibition / physiology*
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Neurons, Afferent / drug effects*
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Neurons, Afferent / metabolism
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Neurons, Afferent / physiology*
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Rats
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Rats, Wistar
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Receptor, PAR-2
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Receptors, Drug / metabolism
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Receptors, Thrombin / metabolism*
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TRPV Cation Channels
Substances
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Receptor, PAR-2
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Receptors, Drug
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Receptors, Thrombin
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TRPV Cation Channels
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TRPV1 receptor
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capsazepine
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Capsaicin