Abstract
Intravascular lymphomatosis, also known as endovascular lymphoma or angiotropic large cell lymphoma, is a rare malignancy typically diagnosed at autopsy. We describe a case in which the diagnosis was made at an early stage. Specific electrodiagnostic findings suggested concomitant polyneuropathy and myopathy. Suspicion of a paraneoplastic syndrome during electrodiagnostic testing prompted muscle biopsy, which revealed myopathy due to the direct infiltration of neoplastic cells. Resultant treatment with a standard chemotherapy regimen not only increased the patient's survival, but also improved neurological function.
Copyright 2002 Wiley Periodicals, Inc. Muscle Nerve 25:000-000, 2002
MeSH terms
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Biopsy
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Cyclophosphamide / therapeutic use*
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Doxorubicin / therapeutic use*
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Humans
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Lymphoma, B-Cell / complications
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Lymphoma, B-Cell / diagnosis
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Lymphoma, B-Cell / drug therapy*
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Lymphoma, B-Cell / pathology
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Male
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Middle Aged
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Muscle, Skeletal / pathology
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Muscular Diseases / etiology
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Muscular Diseases / pathology
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Neoplasm Invasiveness
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Polyneuropathies / etiology
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Prednisone / therapeutic use*
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Treatment Outcome
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Vascular Neoplasms / complications
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Vascular Neoplasms / diagnosis
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Vascular Neoplasms / drug therapy*
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Vascular Neoplasms / pathology
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Vincristine / therapeutic use*
Substances
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Vincristine
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Doxorubicin
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Cyclophosphamide
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Prednisone