Abstract
Single- and Multi-step selection studies were used to test the ability of BMS-284756, ciprofloxacin, levofloxacin, trovafloxacin and moxifloxacin to yield resistant clones from 12 quinolone-susceptible and -resistant Streptococcus pneumoniae strains. Although all quinolones selected, to a greater or lesser degree, for resistant clones with mutations usually in parC or gyrA, BMS-284756 tended to select for resistant clones at a lower rate than other quinolones studied.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Infective Agents / pharmacology*
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Aza Compounds*
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Biological Transport
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Ciprofloxacin / pharmacology
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Drug Resistance, Microbial / genetics
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Drug Resistance, Multiple / genetics
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Fluoroquinolones*
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Humans
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Indoles*
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Levofloxacin
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Microbial Sensitivity Tests
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Moxifloxacin
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Naphthyridines / pharmacology
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Ofloxacin / pharmacology
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Quinolines*
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Quinolones*
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Streptococcus pneumoniae / drug effects*
Substances
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Anti-Infective Agents
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Aza Compounds
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Fluoroquinolones
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Indoles
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Naphthyridines
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Quinolines
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Quinolones
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Ciprofloxacin
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Levofloxacin
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trovafloxacin
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Ofloxacin
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Moxifloxacin
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garenoxacin