Abstract
The hypoglycemic effect of an exo-polymer produced from a submerged mycelial culture of Lentinus edodes was investigated in streptozotocin-induced diabetic rats. The administration of the exo-polymer (200 mg/kg BW) reduced the plasma glucose level by as much as 21.5%, and increased plasma insulin by 22.1% as compared to the control group. It also lowered the plasma total cholesterol and triglyceride levels by 25.1 and 44.5%, respectively. Gel chromatography of the exo-polymer revealed a single peak which is likely to have been a glycoprotein with a molecular weight of 52 kDa and was found to contain 83.5% carbohydrate and 16.5% protein. The Sugar and amino acid compositions of the exo-polymer were analyzed in detail.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Oral
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Alanine Transaminase / blood
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Animals
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Aspartate Aminotransferases / blood
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Biopolymers / chemistry
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Biopolymers / isolation & purification
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Biopolymers / pharmacology
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Biopolymers / therapeutic use*
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Blood Glucose / analysis
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Body Weight / drug effects
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Chromatography, Gel
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Diabetes Mellitus, Experimental / drug therapy
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Feeding Behavior / drug effects
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Hypoglycemic Agents / chemistry
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Hypoglycemic Agents / isolation & purification
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Hypoglycemic Agents / pharmacology
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Hypoglycemic Agents / therapeutic use*
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Male
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Rats
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Rats, Sprague-Dawley
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Shiitake Mushrooms / chemistry*
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Streptozocin
Substances
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Biopolymers
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Blood Glucose
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Hypoglycemic Agents
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Streptozocin
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Aspartate Aminotransferases
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Alanine Transaminase