Structural-functional relationship of pathogen-associated molecular patterns: lessons from BCG cell wall skeleton and mycoplasma lipoprotein M161Ag

Microbes Infect. 2002 Jul;4(9):955-61. doi: 10.1016/s1286-4579(02)01610-6.

Abstract

The innate immune system senses microbial components by signaling receptors and induces phagocytosis by uptake receptors. The Toll-like receptor represents the signaling receptors that cause maturation of dendritic cells, while phagocytosis is supported by other receptor families. We identify the structural signatures of microbial components recognized by these receptors to establish the two-receptor hypothesis in innate immunity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adjuvants, Immunologic
  • Animals
  • Antigens, Bacterial / chemistry
  • Antigens, Bacterial / immunology*
  • Cell Wall / chemistry
  • Cell Wall / immunology*
  • Dendritic Cells / immunology
  • Drosophila Proteins*
  • Immunity, Innate
  • Lipoproteins / chemistry
  • Lipoproteins / immunology*
  • Macrophages / immunology
  • Membrane Glycoproteins / immunology
  • Mycobacterium bovis / immunology*
  • Mycobacterium bovis / pathogenicity
  • Mycoplasma / immunology*
  • Mycoplasma / pathogenicity
  • Receptors, Cell Surface / immunology
  • Structure-Activity Relationship
  • Toll-Like Receptors

Substances

  • Adjuvants, Immunologic
  • Antigens, Bacterial
  • Drosophila Proteins
  • Lipoproteins
  • Membrane Glycoproteins
  • Receptors, Cell Surface
  • Toll-Like Receptors