Abstract
The Up.D base-pair (5-propynyl uracil.diaminopurine) is found to be more effective at non-enzymatic transcription than the corresponding natural T.A pair; under non-enzymatic reaction conditions where the natural T.A base-pair fails, a DNA template bearing Up efficiently directs the incorporation of D into a product RNA strand.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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2-Aminopurine / analogs & derivatives*
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2-Aminopurine / chemistry*
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Adenine / chemistry
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Alkynes / chemistry*
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Autoradiography
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Base Pairing
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DNA Replication
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Electrophoresis, Polyacrylamide Gel
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Templates, Genetic
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Transcription, Genetic*
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Uracil / analogs & derivatives*
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Uracil / chemistry*
Substances
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Alkynes
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5-propynyluracil
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2-Aminopurine
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2,6-diaminopurine
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Uracil
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Adenine