Minimal variation in T-20 binding domain of different HIV-1 subtypes from antiretroviral-naive and -experienced patients

AIDS. 2002 Aug 16;16(12):1684-6. doi: 10.1097/00002030-200208160-00016.

Abstract

In-vitro differences in T-20 susceptibility among HIV-1 subtypes have been reported. We therefore studied the T-20 binding domain of a variety of virus subtypes from both antiretroviral-naive and -experienced patients. Minimal variation in the HR-1 region of gp41 was observed, especially within the region responsible for T-20 resistance. Any subtype differences in T-20 susceptibility do not appear to be related to HR-1 genetic variation.

Publication types

  • Comparative Study

MeSH terms

  • Anti-HIV Agents / metabolism*
  • Base Sequence
  • DNA Primers
  • Enfuvirtide
  • HIV Envelope Protein gp41 / chemistry
  • HIV Envelope Protein gp41 / metabolism*
  • HIV Infections / drug therapy
  • HIV Infections / virology*
  • Humans
  • Peptide Fragments / metabolism*

Substances

  • Anti-HIV Agents
  • DNA Primers
  • HIV Envelope Protein gp41
  • Peptide Fragments
  • Enfuvirtide