Abstract
Mammalian olfactory sensory neurons that express a particular odorant receptor (OR) project axons to the same few glomeruli in the olfactory bulb. In this issue of Neuron, Vassalli et al. use OR minigenes that coexpress histochemical markers and show that the determinants in the sensory neurons required to generate the stereotyped olfactory bulb map are the same as those needed for appropriate expression of the OR.
MeSH terms
-
Animals
-
Cell Differentiation / genetics
-
Gene Expression Regulation, Developmental / physiology*
-
Genetic Engineering / methods
-
Growth Cones / metabolism*
-
Growth Cones / ultrastructure
-
Humans
-
Olfactory Bulb / cytology
-
Olfactory Bulb / embryology*
-
Olfactory Bulb / metabolism
-
Olfactory Pathways / cytology
-
Olfactory Pathways / embryology*
-
Olfactory Pathways / metabolism
-
Olfactory Receptor Neurons / cytology
-
Olfactory Receptor Neurons / embryology*
-
Olfactory Receptor Neurons / metabolism
-
Receptors, Odorant / genetics*
-
Transgenes / genetics*