Abstract
New lipopeptide antibiotics, colourless arylomycins A series and yellow arylomycins B series were detected in the culture filtrate and mycelium extracts of Streptomyces sp. Tü 6075 by HPLC-diode-array and HPLC-electrospray-mass-spectrometry screening. Arylomycins are a family of lipohexapeptide antibiotics, which represent the first examples of biaryl-bridged lipopeptides. They show antibiotic activities against Gram-positive bacteria.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Anti-Bacterial Agents / biosynthesis
-
Anti-Bacterial Agents / isolation & purification*
-
Anti-Bacterial Agents / pharmacology
-
Chromatography, High Pressure Liquid
-
DNA, Bacterial / chemistry
-
DNA, Bacterial / genetics
-
Microbial Sensitivity Tests
-
Peptides, Cyclic / biosynthesis
-
Peptides, Cyclic / isolation & purification*
-
Peptides, Cyclic / pharmacology
-
Polymerase Chain Reaction
-
RNA, Ribosomal, 16S / chemistry
-
RNA, Ribosomal, 16S / genetics
-
Sequence Analysis, DNA
-
Soil Microbiology
-
Streptomyces / chemistry
-
Streptomyces / classification
-
Streptomyces / genetics
-
Streptomyces / metabolism*
Substances
-
Anti-Bacterial Agents
-
DNA, Bacterial
-
Peptides, Cyclic
-
RNA, Ribosomal, 16S