Arylomycins A and B, new biaryl-bridged lipopeptide antibiotics produced by Streptomyces sp. Tü 6075. I. Taxonomy, fermentation, isolation and biological activities

J Antibiot (Tokyo). 2002 Jun;55(6):565-70. doi: 10.7164/antibiotics.55.565.

Abstract

New lipopeptide antibiotics, colourless arylomycins A series and yellow arylomycins B series were detected in the culture filtrate and mycelium extracts of Streptomyces sp. Tü 6075 by HPLC-diode-array and HPLC-electrospray-mass-spectrometry screening. Arylomycins are a family of lipohexapeptide antibiotics, which represent the first examples of biaryl-bridged lipopeptides. They show antibiotic activities against Gram-positive bacteria.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / biosynthesis
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology
  • Chromatography, High Pressure Liquid
  • DNA, Bacterial / chemistry
  • DNA, Bacterial / genetics
  • Microbial Sensitivity Tests
  • Peptides, Cyclic / biosynthesis
  • Peptides, Cyclic / isolation & purification*
  • Peptides, Cyclic / pharmacology
  • Polymerase Chain Reaction
  • RNA, Ribosomal, 16S / chemistry
  • RNA, Ribosomal, 16S / genetics
  • Sequence Analysis, DNA
  • Soil Microbiology
  • Streptomyces / chemistry
  • Streptomyces / classification
  • Streptomyces / genetics
  • Streptomyces / metabolism*

Substances

  • Anti-Bacterial Agents
  • DNA, Bacterial
  • Peptides, Cyclic
  • RNA, Ribosomal, 16S