Abstract
This article deals with our recent studies on the synthesis of BNAs (Bridged Nucleic Acids), novel nucleic acid analogs bearing a preorganized sugar conformation by a bridged structure. Duplex- and triplex-forming abilities of the BNA modified oligonucleotides are also described.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Base Pairing
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Bridged Bicyclo Compounds, Heterocyclic / chemical synthesis
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Bridged Bicyclo Compounds, Heterocyclic / chemistry
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Molecular Structure
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Nucleic Acid Conformation
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Nucleic Acids / chemical synthesis*
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Nucleic Acids / chemistry
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Oligodeoxyribonucleotides, Antisense / chemistry
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Pentoses / chemical synthesis*
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Pentoses / chemistry
Substances
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Bridged Bicyclo Compounds, Heterocyclic
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Nucleic Acids
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Oligodeoxyribonucleotides, Antisense
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Pentoses