Somatic cell nuclear transfer

Nature. 2002 Oct 10;419(6907):583-6. doi: 10.1038/nature01079.

Abstract

Cloning by nuclear transfer from adult somatic cells is a remarkable demonstration of developmental plasticity. When a nucleus is placed in oocyte cytoplasm, the changes in chromatin structure that govern differentiation can be reversed, and the nucleus can be made to control development to term.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cattle
  • Cell Cycle
  • Cell Differentiation
  • Cloning, Organism*
  • Embryonic and Fetal Development
  • Fetal Death
  • Forecasting
  • Gene Expression Regulation, Developmental
  • Goats
  • Mice
  • Nuclear Transfer Techniques*
  • Oocytes / cytology
  • Ploidies
  • Sheep
  • Swine