The therapeutic potential of modulators of the Hedgehog-Gli signaling pathway

Barbara Stecca; Ariel Ruiz i Altaba

doi:10.1186/1475-4924-1-9

The therapeutic potential of modulators of the Hedgehog-Gli signaling pathway

J Biol. 2002 Nov 6;1(2):9. doi: 10.1186/1475-4924-1-9.

Authors

Barbara Stecca¹, Ariel Ruiz i Altaba

Affiliation

¹ Skirball Institute, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA.

Abstract

The discovery of small molecules that act as agonists and antagonists of the Hedgehog-Gli signaling pathway, which plays important roles in the embryo and adult, opens a new avenue for the treatment of diseases caused by aberrant suppression or activation of this complex pathway.

Publication types

Review

MeSH terms

Animals
Hedgehog Proteins
Humans
Oncogene Proteins / agonists
Oncogene Proteins / antagonists & inhibitors
Oncogene Proteins / metabolism*
Oncogene Proteins / therapeutic use*
Signal Transduction / drug effects*
Trans-Activators / agonists
Trans-Activators / antagonists & inhibitors
Trans-Activators / metabolism*
Trans-Activators / therapeutic use*
Transcription Factors / agonists
Transcription Factors / antagonists & inhibitors
Transcription Factors / metabolism*
Transcription Factors / therapeutic use*
Zinc Finger Protein GLI1

Substances

Hedgehog Proteins
Oncogene Proteins
Trans-Activators
Transcription Factors
Zinc Finger Protein GLI1