Endophenazines A-D, new phenazine antibiotics from the arthropod associated endosymbiont Streptomyces anulatus. I. Taxonomy, fermentation, isolation and biological activities

J Antibiot (Tokyo). 2002 Sep;55(9):794-800. doi: 10.7164/antibiotics.55.794.

Abstract

Four new members of the phenazine family, endophenazines A-D, and the already known phenazine-1-carboxylic acid (tubermycin B) were detected in the culture broth of various endosymbiotic Streptomyces anulatus strains by chemical screening in a combination of TLC-staining reagents and HPLC-diode array analysis. The endosymbiotic strains were isolated from four different arthropod hosts at various sites. The new phenazine compounds showed antimicrobial activities against Gram-positive bacteria and some filamentous fungi, and herbicidal activity against Lemna minor (duckweed).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology
  • Arthropods / microbiology*
  • Bacteria / drug effects
  • Fermentation*
  • Phenazines / isolation & purification*
  • Phenazines / pharmacology
  • Streptomyces / classification*
  • Streptomyces / metabolism
  • Symbiosis*

Substances

  • Anti-Bacterial Agents
  • Phenazines
  • endophenazine A
  • endophenazine B
  • endophenazine C
  • endophenazine D