Structure-activity and crystallographic analysis of benzophenone derivatives-the potential anticancer agents

Bioorg Med Chem Lett. 2003 Jan 6;13(1):101-5. doi: 10.1016/s0960-894x(02)00850-8.

Abstract

Compounds 1-5, structurally related to combretastatin A-4 showed excellent cytotoxic activities against a panel of human cancer cell lines including multi-drug resistant cell lines. The X-ray three-dimensional structural analysis shows that proton donor in B ring may be required for cytotoxic activity, with intermolecular hydrogen bonding playing an important role.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology
  • Benzophenones / chemical synthesis*
  • Benzophenones / pharmacology
  • Bibenzyls / chemistry
  • Cell Cycle / drug effects
  • Crystallography, X-Ray
  • Drug Resistance, Multiple
  • Drug Screening Assays, Antitumor
  • Humans
  • Inhibitory Concentration 50
  • Models, Molecular
  • Molecular Structure
  • Stilbenes*
  • Structure-Activity Relationship
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • Benzophenones
  • Bibenzyls
  • Stilbenes
  • combretastatin