beta-Homolysine oligomers: a new class of Trojan carriers

Bioorg Med Chem Lett. 2003 Jan 20;13(2):247-51. doi: 10.1016/s0960-894x(02)00885-5.

Abstract

We describe the design, synthesis and cell-membrane translocation properties of a series of beta-peptides with the general sequence fluorescein-Adoa-(beta-homolysine)(n)-NH(2), n=5-8 and Adoa=8-amino-3,6-dioxaoctanoic acid. These beta-peptides are able to cross the cytoplasmic membrane and accumulate in the nucleus of mammalian cells.

MeSH terms

  • Animals
  • Cell Line
  • Cell Membrane / metabolism
  • Drug Design
  • Fluorescein / chemical synthesis
  • Fluorescein-5-isothiocyanate
  • Image Cytometry
  • Oligopeptides / chemical synthesis*
  • Oligopeptides / chemistry*
  • Oligopeptides / metabolism
  • Oligopeptides / pharmacology*
  • Sodium Azide / pharmacology
  • Vasodilator Agents / pharmacology

Substances

  • Oligopeptides
  • Vasodilator Agents
  • Sodium Azide
  • Fluorescein-5-isothiocyanate
  • Fluorescein