Abstract
We describe the design, synthesis and cell-membrane translocation properties of a series of beta-peptides with the general sequence fluorescein-Adoa-(beta-homolysine)(n)-NH(2), n=5-8 and Adoa=8-amino-3,6-dioxaoctanoic acid. These beta-peptides are able to cross the cytoplasmic membrane and accumulate in the nucleus of mammalian cells.
MeSH terms
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Animals
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Cell Line
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Cell Membrane / metabolism
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Drug Design
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Fluorescein / chemical synthesis
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Fluorescein-5-isothiocyanate
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Image Cytometry
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Oligopeptides / chemical synthesis*
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Oligopeptides / chemistry*
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Oligopeptides / metabolism
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Oligopeptides / pharmacology*
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Sodium Azide / pharmacology
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Vasodilator Agents / pharmacology
Substances
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Oligopeptides
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Vasodilator Agents
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Sodium Azide
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Fluorescein-5-isothiocyanate
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Fluorescein