Pharmacology of synaptic transmission in the enteric nervous system

Curr Opin Pharmacol. 2002 Dec;2(6):623-9. doi: 10.1016/s1471-4892(02)00212-6.

Abstract

Recent data indicate that there are multiple mechanisms mediating fast and slow synaptic excitation in the enteric nervous system. However, these data also suggest that both the neurotransmitters and the receptors mediating fast and slow synaptic transmission in the myenteric plexus are organized in a polarity- (ascending versus descending) and pathway- (excitatory versus inhibitory) specific manner.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Digestive System / drug effects*
  • Digestive System / innervation*
  • Gastrointestinal Agents / pharmacology*
  • Humans
  • Neurotransmitter Agents / metabolism
  • Receptors, Neurotransmitter / metabolism
  • Synapses / drug effects*
  • Synapses / metabolism
  • Synaptic Transmission / drug effects*

Substances

  • Gastrointestinal Agents
  • Neurotransmitter Agents
  • Receptors, Neurotransmitter