Combination platelet glycoprotein IIb/IIIa receptor and lepirudin administration during percutaneous coronary intervention in patients with heparin-induced thrombocytopenia

Catheter Cardiovasc Interv. 2003 Jan;58(1):65-8. doi: 10.1002/ccd.10393.

Abstract

We evaluated a combination therapy using glycoprotein IIb/IIIa receptor antagonism and direct thrombin inhibition in nine patients with heparin-induced thrombocytopenia (HIT) undergoing 10 percutaneous coronary interventions (PCIs). In selected patients with HIT, the combination of a direct thrombin inhibitor, lepirudin, and abciximab, tirofiban, or eptifibatide appears to be a safe and effective anticoagulation strategy for PCI.

Publication types

  • Review

MeSH terms

  • Abciximab
  • Aged
  • Aged, 80 and over
  • Angioplasty, Balloon, Coronary*
  • Antibodies, Monoclonal / administration & dosage
  • Antibodies, Monoclonal / therapeutic use
  • Anticoagulants / administration & dosage*
  • Anticoagulants / therapeutic use*
  • Drug Therapy, Combination
  • Eptifibatide
  • Female
  • Fibrinolytic Agents / adverse effects*
  • Heparin / adverse effects*
  • Hirudins / administration & dosage*
  • Hirudins / analogs & derivatives*
  • Humans
  • Immunoglobulin Fab Fragments / administration & dosage
  • Immunoglobulin Fab Fragments / therapeutic use
  • Male
  • Middle Aged
  • Peptides / administration & dosage
  • Peptides / therapeutic use
  • Platelet Aggregation Inhibitors / administration & dosage
  • Platelet Aggregation Inhibitors / therapeutic use
  • Platelet Glycoprotein GPIIb-IIIa Complex / administration & dosage
  • Platelet Glycoprotein GPIIb-IIIa Complex / antagonists & inhibitors*
  • Platelet Glycoprotein GPIIb-IIIa Complex / therapeutic use*
  • Recombinant Proteins / administration & dosage*
  • Recombinant Proteins / therapeutic use*
  • Thrombocytopenia / chemically induced*
  • Thrombocytopenia / drug therapy*
  • Thrombocytopenia / surgery
  • Tirofiban
  • Tyrosine / administration & dosage
  • Tyrosine / analogs & derivatives
  • Tyrosine / therapeutic use

Substances

  • Antibodies, Monoclonal
  • Anticoagulants
  • Fibrinolytic Agents
  • Hirudins
  • Immunoglobulin Fab Fragments
  • Peptides
  • Platelet Aggregation Inhibitors
  • Platelet Glycoprotein GPIIb-IIIa Complex
  • Recombinant Proteins
  • Tyrosine
  • Heparin
  • Tirofiban
  • Eptifibatide
  • Abciximab
  • lepirudin