Synaptogenesis: Wnt and TGF-beta take centre stage

Curr Biol. 2003 Jan 21;13(2):R60-2. doi: 10.1016/s0960-9822(02)01429-x.

Abstract

The formation of functional synapses requires precise coordination between neurons and their synaptic targets. Recent studies have identified two signaling molecules, Wnt and TGF-beta, which are required for formation and growth of the neuromuscular synapse.

MeSH terms

  • Animals
  • Drosophila / growth & development
  • Drosophila / physiology
  • Drosophila Proteins / physiology
  • Models, Neurological
  • Neuromuscular Junction / growth & development
  • Neuromuscular Junction / physiology
  • Proto-Oncogene Proteins / physiology*
  • Signal Transduction
  • Synapses / physiology*
  • Transforming Growth Factor beta / physiology*
  • Wnt Proteins
  • Wnt1 Protein
  • Zebrafish Proteins*

Substances

  • Drosophila Proteins
  • Proto-Oncogene Proteins
  • Transforming Growth Factor beta
  • Wnt Proteins
  • Wnt1 Protein
  • Zebrafish Proteins
  • wg protein, Drosophila