Heterogeneous Epstein-Barr virus latent gene expression in AIDS-associated lymphomas and in type I Burkitt's lymphoma cell lines

R Touitou; H Arbach; C Cochet; J Feuillard; A Martin; M Raphaël; I Joab

doi:10.1099/vir.0.18687-0

Heterogeneous Epstein-Barr virus latent gene expression in AIDS-associated lymphomas and in type I Burkitt's lymphoma cell lines

J Gen Virol. 2003 Apr;84(Pt 4):949-957. doi: 10.1099/vir.0.18687-0.

Authors

R Touitou¹, H Arbach¹, C Cochet¹, J Feuillard², A Martin², M Raphaël², I Joab¹

Affiliations

¹ INSERM EPI 03-34, IUH, Hôpital Saint-Louis, Paris, France.
² Hématologie Biologique, Hôpital Avicenne, EA 1625, UFR SMBH, Université Paris 13 Bobigny, France.

PMID: 12655096
DOI: 10.1099/vir.0.18687-0

Abstract

Epstein-Barr virus (EBV) is associated with lymphoma in immunocompromised patients. This study provides evidence that the expression of EBV nuclear antigen-3 genes can be directed from the F promoter in different type I Burkitt's lymphoma cell lines and in some lymphomas from human immunodeficiency virus-infected patients. This expression occurs predominantly after induction of the EBV lytic cycle.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Base Sequence
Burkitt Lymphoma / virology*
Cell Line
DNA, Viral / genetics
Epstein-Barr Virus Nuclear Antigens / analysis
Epstein-Barr Virus Nuclear Antigens / genetics
Epstein-Barr Virus Nuclear Antigens / metabolism*
Gene Expression*
Herpesvirus 4, Human / genetics
Herpesvirus 4, Human / physiology*
Humans
Immunohistochemistry
Lymphoma, AIDS-Related / virology*
Molecular Sequence Data
Promoter Regions, Genetic
RNA, Messenger / genetics
Reverse Transcriptase Polymerase Chain Reaction
Virus Latency*

Substances

DNA, Viral
EBNA-3B antigen
Epstein-Barr Virus Nuclear Antigens
RNA, Messenger