Prospective study of morbidity associated with snakebite envenomation

J Toxicol Clin Toxicol. 2003;41(2):125-30. doi: 10.1081/clt-120019127.

Abstract

Background: The morbidity associated with snakebite envenomation has not been well documented.

Method: Using a standardized questionnaire all patients with snakebite reported to a regional poison center during the year 2001 were followed after hospital discharge by telephone until resolution of symptoms.

Results: One hundred and twenty-eight snakebite cases were reported, of which 16 (12.5%) were lost to follow-up and 31 (24.2%) reported no progression of symptoms beyond puncture and were deemed "dry bites." Eighty-one (63.3%) patients were followed for the duration of symptoms. Age ranged from 1 to 86 years with a mean of 32 years. There were 64 males (79%). The snakes were identified as copperhead (n = 57), unidentified venomous (n = 17), timber rattlesnake (n = 6), and cottonmouth (n = 1). All patients were initially evaluated in a hospital emergency department of which 51 were admitted. Nine patients received antivenin. Of the 37 patients who had a job, 33 lost a mean of 14 days of work (SD +/- 18.1). Mean duration of edema was reported as 11.4 days (S.D +/- 12). Recurrent edema frequently occurred with limb activity. Pain was scored on a scale of 1 to 10, with a mean score of 4.8 (SD +/- 2.7). Mean duration of pain was reported as 7.8 days (SD +/- 6.4). Thirty patients required accommodation for ambulation including crutches (n = 11), limp (n = 11), and no shoes or loose shoes (n = 14). Of the 26 patients bitten on the hand or finger, duration of reduced function persisted for a mean of 14.3 days (SD +/- 10.4) and reduction of hand strength persisted for a mean of 22 days (SD +/- 25.5). Five patients had poorly healing wounds at the bite site which persisted from 14 to 77 days with a mean of 45 days (SD +/- 22.8)

Conclusion: In this study snakebite resulted in significant duration and extent of morbidity in a majority of patients.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Animals
  • Child
  • Child, Preschool
  • Crotalid Venoms / poisoning*
  • Edema / epidemiology
  • Edema / pathology
  • Extremities
  • Female
  • Humans
  • Infant
  • Male
  • Middle Aged
  • Muscle Weakness / epidemiology
  • Muscle Weakness / pathology
  • Pain / epidemiology
  • Pain / etiology
  • Pain Measurement
  • Poison Control Centers
  • Prospective Studies
  • Snake Bites / complications*
  • Snake Bites / epidemiology*
  • Snakes
  • Surveys and Questionnaires
  • United States / epidemiology
  • Walking

Substances

  • Crotalid Venoms