Expression of Heparin-Binding Epidermal Growth Factor-like Growth Factor in Pancreatic Adenocarcinoma

Yasuhiro Ito; Shigeki Higashiyama; Tsutomu Takeda; Yasuko Yamamoto; Ken-Ichi Wakasa; Nariaki Matsuura

Expression of Heparin-Binding Epidermal Growth Factor-like Growth Factor in Pancreatic Adenocarcinoma

Int J Gastrointest Cancer. 2001;29(1):47-52.

Authors

Yasuhiro Ito¹, Shigeki Higashiyama, Tsutomu Takeda, Yasuko Yamamoto, Ken-Ichi Wakasa, Nariaki Matsuura

Affiliation

¹ Department of Surgery, Osaka Seamen's Insurance Hospital, 1-8-30, Chikko, Minato-ku, Osaka 552-0021, Japan; Department of Pathology, Osaka University Faculty of Medicine, 1-7, Yamadaoka, Suita, Osaka 565-0871, Japan.

PMID: 12754404

Abstract

Heparin-binding epidermal growth factor-likegrowth factor (HB-EGF) belongs to the EGF familyand was originally identified in the conditionedmedium of a human histiotic lymphoma cell line, U937 (1). This protein is synthesized as a preproformof 208 amino acids (2), is expressed as amembrane-anchored HB-EGF, and is released as asoluble form of 87 amino acids after being processedby protease (1,2). HB-EGF binds to the EGF receptor(EGF-R) in competition with EGF (3), and exogenoussoluble HB-EGF is known to stimulateDNA synthesis in primary rat hepatocytes in a dosedependentmanner (4).