Abstract
The 3D jury system has predicted the methyltransferase fold for the nsp13 protein of the SARS coronavirus. Based on the conservation of a characteristic tetrad of residues, the mRNA cap-1 methyltransferase function has been assigned to this protein, which has potential implications for antiviral therapy.
MeSH terms
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Carrier Proteins / genetics*
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Carrier Proteins / metabolism
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Genome, Viral*
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Methyltransferases / genetics*
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Methyltransferases / metabolism
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Models, Molecular
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Protein Structure, Tertiary / genetics
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RNA, Messenger / metabolism*
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Severe Acute Respiratory Syndrome / virology*
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Severe acute respiratory syndrome-related coronavirus / enzymology*
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Severe acute respiratory syndrome-related coronavirus / genetics*
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TNF Receptor-Associated Factor 3
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Tumor Necrosis Factor Receptor-Associated Peptides and Proteins*
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Viral Proteins / genetics*
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Viral Proteins / metabolism
Substances
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Carrier Proteins
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RNA, Messenger
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TNF Receptor-Associated Factor 3
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TRAF3 protein, human
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Tumor Necrosis Factor Receptor-Associated Peptides and Proteins
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Viral Proteins
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Methyltransferases