Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell-dependent B cell responses

Nat Immunol. 2003 Aug;4(8):765-72. doi: 10.1038/ni947. Epub 2003 Jun 29.

Abstract

Costimulation through the inducible costimulator (ICOS) and its ligand (ICOSL) is essential for T cell-dependent B cell responses, but the cellular and temporal dynamics underlying its in vivo effects are poorly defined. Here we have shown that Icosl(-/-) and Icos(-/-) mice had similar phenotypes and that ICOS-ICOSL costimulation modulated the early but not late phases of IgG1 affinity maturation. Exploiting the adoptive transfer of T or B cells from primed Icosl(-/-) mice, we provided genetic evidence that costimulation through ICOSL was essential for primary but not secondary helper T cell responses and for the control of both T and B cell activities, resulting in T cell-dependent IgG1 production.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, Differentiation, T-Lymphocyte / immunology*
  • B-Lymphocytes / immunology*
  • Gene Deletion
  • Immunoglobulin G / immunology
  • Inducible T-Cell Co-Stimulator Ligand
  • Inducible T-Cell Co-Stimulator Protein
  • Lymphocyte Cooperation / immunology*
  • Mice
  • Proteins / genetics
  • Proteins / metabolism*
  • T-Lymphocytes, Helper-Inducer / immunology*

Substances

  • Antigens, Differentiation, T-Lymphocyte
  • Icos protein, mouse
  • Icosl protein, mouse
  • Immunoglobulin G
  • Inducible T-Cell Co-Stimulator Ligand
  • Inducible T-Cell Co-Stimulator Protein
  • Proteins