Abstract
Despite considerable advances in HIV science in the past 20 years, the reason why HIV-1 infection is pathogenic is still debated and the goal of eradicating HIV-1 infection remains elusive. A deeper understanding of the interplay between HIV-1 and its host and why simian immunodeficiency virus (SIV) is nonpathogenic in some natural hosts may provide a few answers.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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CD4-Positive T-Lymphocytes / virology*
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Dendritic Cells / virology
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HIV Infections / pathology
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HIV Infections / virology
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HIV-1 / pathogenicity*
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HIV-1 / physiology
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Host-Parasite Interactions
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Humans
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Macrophages / virology
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Simian Immunodeficiency Virus / pathogenicity
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Virus Replication / physiology*