Mild method for Ullmann coupling reaction of amines and aryl halides

Dawei Ma; Qian Cai; Hui Zhang

doi:10.1021/ol0346584

Mild method for Ullmann coupling reaction of amines and aryl halides

Org Lett. 2003 Jul 10;5(14):2453-5. doi: 10.1021/ol0346584.

Authors

Dawei Ma¹, Qian Cai, Hui Zhang

Affiliation

¹ State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, 354 Fenglin Lu, Shanghai 200032, China. madw@pub.sioc.ac.cn

PMID: 12841753
DOI: 10.1021/ol0346584

Abstract

[reaction: see text] Ullmann-type aryl amination of aryl iodides and aryl bromides in DMSO at 40-90 degrees C gave the corresponding N-arylamines or N,N-diarylamines in good to excellent yields by using either N-methylglycine or L-proline as the ligand.