Taenia crassiceps cysticercosis in mice does not increase the carcinogenic effect of methyl-nitrosourea

Exp Parasitol. 2003 Mar-Apr;103(3-4):169-70. doi: 10.1016/s0014-4894(03)00088-2.

Abstract

An association between brain cysticercosis and malignant neoplasms in humans has recently been reported. To explore the possibility of a potentiating effect of cysticercosis on carcinogenesis mice infected with Taenia crassiceps cysticerci were exposed to the carcinogenic substance methyl-nitrosourea; 35% of them developed lymphoma, in contrast with 50% of control non-infected animals exposed to MNU. In this experimental model of cysticercosis we did not find a potentiating effect of peritoneal cysticercosis on the carcinogenicity of MNU.

MeSH terms

  • Animals
  • Carcinogens / toxicity*
  • Cysticercosis / parasitology
  • Cysticercosis / physiopathology*
  • Cysticercus / pathogenicity
  • Female
  • Incidence
  • Lymphoma / chemically induced*
  • Lymphoma / epidemiology
  • Methylnitrosourea / toxicity*
  • Mice
  • Mice, Inbred BALB C
  • Peritoneal Cavity / parasitology

Substances

  • Carcinogens
  • Methylnitrosourea