CSF-1 as a regulator of macrophage activation and immune responses

Arch Immunol Ther Exp (Warsz). 2003;51(3):169-77.

Abstract

Macrophage activation is a key determinant of susceptibility and pathology in a variety of inflammatory diseases. The extent of macrophage activation is tightly regulated by a number of pro-inflammatory cytokines (e.g. IFN-gamma, IL-2, GM-CSF, IL-3) and anti-inflammatory cytokines (e.g. IL-4, IL-10, TGF-beta). Macrophage colony-stimulating factor (CSF-1/M-CSF) is a key differentiation, growth and survival factor for monocytes/macrophages and osteoclasts. The role of this factor in regulating macrophage activation is often overlooked. This review will summarize our current understanding of the effects of CSF-1 on the activation state of mature macrophages and its role in regulating immune responses.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Cell Division
  • Cell Survival
  • Cytokines / metabolism
  • Humans
  • Infections
  • Inflammation
  • Leukocytes / metabolism
  • Lipopolysaccharides / metabolism
  • Macrophage Activation*
  • Macrophage Colony-Stimulating Factor / metabolism
  • Macrophage Colony-Stimulating Factor / physiology*
  • Macrophages / metabolism*
  • Membrane Glycoproteins / metabolism
  • Receptors, Cell Surface / metabolism
  • Toll-Like Receptors

Substances

  • Cytokines
  • Lipopolysaccharides
  • Membrane Glycoproteins
  • Receptors, Cell Surface
  • Toll-Like Receptors
  • Macrophage Colony-Stimulating Factor