Myxoid liposarcoma confirmed by TLS/FUS-CHOP fusion transcripts

Dermatol Surg. 2003 Sep;29(9):980-1. doi: 10.1046/j.1524-4725.2003.29265.x.

Abstract

Described here is the use of detecting TLS/FUS-CHOP fusion transcripts to confirm the diagnosis of a myxoid liposarcoma by nested reverse transcription-polymerase chain reaction assay using archival formalin-fixed, paraffin-embedded tissues of a young man with a benign-looking myxoid tumor on his upper extremity, which is often misdiagnosed clinically or histopathologically as a benign tumor.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Alternative Splicing / genetics*
  • Arm
  • CCAAT-Enhancer-Binding Proteins / genetics*
  • Humans
  • Liposarcoma, Myxoid / diagnosis
  • Liposarcoma, Myxoid / genetics*
  • Male
  • Oncogene Proteins, Fusion / genetics*
  • RNA, Neoplasm / genetics*
  • RNA-Binding Protein FUS / genetics*
  • Reverse Transcriptase Polymerase Chain Reaction / methods
  • Soft Tissue Neoplasms / diagnosis
  • Soft Tissue Neoplasms / genetics*
  • Transcription Factor CHOP

Substances

  • CCAAT-Enhancer-Binding Proteins
  • Oncogene Proteins, Fusion
  • RNA, Neoplasm
  • RNA-Binding Protein FUS
  • TLS-CHOP fusion protein, human
  • Transcription Factor CHOP