Abstract
Described here is the use of detecting TLS/FUS-CHOP fusion transcripts to confirm the diagnosis of a myxoid liposarcoma by nested reverse transcription-polymerase chain reaction assay using archival formalin-fixed, paraffin-embedded tissues of a young man with a benign-looking myxoid tumor on his upper extremity, which is often misdiagnosed clinically or histopathologically as a benign tumor.
MeSH terms
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Adult
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Alternative Splicing / genetics*
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Arm
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CCAAT-Enhancer-Binding Proteins / genetics*
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Humans
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Liposarcoma, Myxoid / diagnosis
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Liposarcoma, Myxoid / genetics*
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Male
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Oncogene Proteins, Fusion / genetics*
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RNA, Neoplasm / genetics*
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RNA-Binding Protein FUS / genetics*
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Reverse Transcriptase Polymerase Chain Reaction / methods
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Soft Tissue Neoplasms / diagnosis
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Soft Tissue Neoplasms / genetics*
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Transcription Factor CHOP
Substances
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CCAAT-Enhancer-Binding Proteins
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Oncogene Proteins, Fusion
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RNA, Neoplasm
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RNA-Binding Protein FUS
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TLS-CHOP fusion protein, human
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Transcription Factor CHOP