Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells

V Kh Khavinson; I E Bondarev; A A Butyugov

doi:10.1023/a:1025493705728

Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells

Bull Exp Biol Med. 2003 Jun;135(6):590-2. doi: 10.1023/a:1025493705728.

Authors

V Kh Khavinson¹, I E Bondarev, A A Butyugov

Affiliation

¹ St. Petersburg Institute of Bioregulation and Gerontology, North-Western Division of Russian Academy of Medical Sciences. ibg@medport.ru

PMID: 12937682
DOI: 10.1023/a:1025493705728

Abstract

Addition of Epithalon peptide in telomerase-negative human fetal fibroblast culture induced expression of the catalytical subunit, enzymatic activity of telomerase, and telomere elongation, which can be due to reactivation of telomerase gene in somatic cells and indicates the possibility of prolonging life span of a cell population and of the whole organism.

MeSH terms

Animals
Fibroblasts / cytology
Fibroblasts / physiology*
Flow Cytometry
HeLa Cells
Humans
In Situ Hybridization, Fluorescence
Oligopeptides / pharmacology*
Protein Subunits / genetics
Protein Subunits / metabolism
Telomerase / genetics
Telomerase / metabolism*
Telomere / metabolism*

Substances

Oligopeptides
Protein Subunits
Telomerase
alanyl-glutamyl-aspartyl-glycine